Public Defence: Mette Eskild Bornstedt, December 12th 2022

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Cand.med. Mette Eskild Bornstedt at Institute of Clinical Medicine will be defending the thesis “The effect of vitamin D metabolites on glucose-stimulated insulin secretion (GSIS) and gene expression in murine insulin producing β-cells and pancreatic islets – an experimental study” for the degree of PhD (Philosophiae Doctor).

Time and place: Dec. 12, 2022 1:15 PM, Rødt auditorium i Laboratoriebygget (25), Ullevål universitetssykehus, Kirkeveien 166

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End-stage renal disease: incidence and prediction by coronary heart disease, and educational level. Follow-up from diagnosis of childhood-onset type 1 diabetes throughout Norway 1973–2017.

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Available online: April 6, 2022

Saeed M, Stene LC, Reisæter AV, Jenssen TG, Tell GS, Tapia G, Joner G, Skrivarhaug T. Annals of Epidemology: https://doi.org/10.1016/j.annepidem.2022.03.015

Purpose: To investigate incidence of end-stage renal disease (ESRD), and the association of education and coronary heart disease (CHD) with ESRD, in subjects throughout Norway followed from the diagnosis of childhood-onset type 1 diabetes.

Mortality trends in type 1 diabetes: a multicountry analysis of six population-based cohorts

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Paz L. D. Ruiz, Lei Chen, Jedidiah I. Morton, Agus Salim, Bendix Carstensen, Edward W. Gregg, Meda E. Pavkov, Manel Mata-Cases, Didac Mauricio, Gregory A. Nichols, Santa Pildava, Stephanie H. Read, Sarah H. Wild, Jonathan E. Shaw & Dianna J. Magliano Diabetologia (2022)

People with type 1 diabetes have a higher risk of mortality than do people without diabetes, but it is unclear how the excess risk of death in people with type 1 diabetes has changed over time.

In this study we assembled aggregate data on mortality during the period 2000–2016 in people with type 1 diabetes aged 0–79 years from Australia, Denmark, Latvia, Scotland, Spain (Catalonia) and the USA (Kaiser Permanente). We found an all-cause mortality rates in people with type 1 diabetes in the six data sources from 2000 to 2016. The excess mortality in people with type 1 diabetes relative to those without diabetes, declined over time in half of the six included data sources. People with type 1 diabetes still had a 2–5 times higher risk of death compared to those without diabetes Continuous improvement in the multidimensional management for people with type 1 diabetes is critical for on-going reductions in mortality.

How Long-Term Physical Activity May Reduce Insulin Resistance

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Insulin resistance is a core finding in patients with type 2 diabetes mellitus (T2DM) and physical activity has the potential of improving insulin resistance. In a newly published review, Sindre Lee Ødegaard and co-workers describe a model of potential mechanisms behind the beneficial effects of physical activity on insulin resistance. They briefly summarize an integrated physiological perspective on insulin resistance and describe the effects of long-term PA on signaling molecules involved in cellular responses.

https://www.mdpi.com/2218-1989/12/3/208