Outcomes & Multi-morbidity In Type 2 diabetes (OMIT) – a national registry-based observational cohort with focus on care and treatment of key high-risk groups in Norway

The “Outcomes & Multi-morbidity in Type 2 Diabetes” (OMIT) project aims to study high-risk patients with type 2 diabetes who are often omitted from prospective clinical trials (hence the acronym OMIT).

Patients treated in Norwegian general practice or at out-patient hospital clinics are identified in a linkage between the ROSA-4 register and the Norwegian Diabetes Register for Adults (NDR-A) (2006-2019, N=52,935) in order to study high-risk groups (1) young onset diabetes, 2) elderly,  3) ethnic minorities and 4) low socio-economic status) in relation to key clinical topics:
1) multi-morbidity,
2) real-life anti-diabetic drug utilization and performance, and
3) variability in disease control.

To analyse confounders, exposures and outcomes in observational data, ROSA4/NDR-A is linked to the Norwegian Prescription Database, the Norwegian Population Register, Statistics Norway and data from the Norwegian Directorate of Health. 

Status: one postdoc and one PhD-candidate work on the project, two papers in preparation.

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Publications 2022:
Cohort profile: Outcomes & Multi-morbidity In Type 2 diabetes (OMIT) - a national registry-based observational cohort with focus on care and treatment of key high-risk groups in Norway. Forster RB, Strandberg RB, Bø Tibballs KL, Nøkleby K, Berg TJ, Iversen T, Hagen TP, Richardsen KR, Cooper J, Sandberg S, Løvaas KF, Nilsen RM, Iversen MM, Jenum AK, Buhl ES.BMJ Open. 2022 May 11;12(5):e054840. doi: 10.1136/bmjopen-2021-05484

Lower education and immigrant background are associated with lower participation in a diabetes education program - Insights from adult patients in the Outcomes & Multi-morbidity In Type 2 diabetes cohort (OMIT). Strandberg RB, Nilsen RM, Pouwer F, Igland J, Forster RB, Jenum AK, Buhl ES, Iversen MM.Patient Educ Couns. 2023 Feb;107:107577. doi: 10.1016/j.pec.2022.107577. Epub 2022 Nov 2

Primary investigator: Senior researcher Esben Selmer Buhl (MD, PhD) with Prof.Emeritus Anne Karen Jenum (MD, PhD) as co-PI

Co-investigators/participants (internal and external):  
Rachel Bedenis Forster1, Ragnhild Bjarkøy Strandberg2, Katrina Tibballs1, Kjersti Nøkkleby1, Tore Julsrud Berg3,4, Tor Iversen4, Terje Hagen4, Kåre Rønn Richardsen5, John Cooper6,7, Tor Claudi8, Sverre Sandberg6,9, Karianne Fjeld Løvaas6, Roy Miodini Nilsen2, Marjolein M.Iversen2, Anne Karen Jenum1 and Esben Selmer Buhl1 †

1 General Practice Research Unit (AFE), Department of General Practice, Institute of Health and Society, University of Oslo, Norway
2 Department of Health and Caring science, Western Norway University of Applied Sciences (HVL) (Norway)
3 Institute of Clinical Medicine , Oslo University (UiO) (Norway)
4 Department of Endocrinology, Oslo University Hospital (OUS) (Norway)
4 Institute of Health and Society, Department of Health Management and Health Economics, Oslo University (UiO) (Norway)
5 Department of Physiotherapy, Falculty of Health Sciences Oslo Metropolitan University (OsloMet)(Norway)
6 Norwegian Quality Improvement of Laboratory Examinations, Haraldsplass Deaconess Hospital, Bergen (HDS) (Norway) 
7 Division of Medicine, Stavanger University Hospital (SUS) (Norway)
8 Medical Centre, Nordland Hospital (NLSH) (Norway)
9 Department of Global Public Health and Primary Care, University of Bergen (UiB) (Norway)

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