Tmem27- marker for ß-cell mass
Background:
The total amount of secreted insulin depends on the absolute number of the ß-cells (ß-cell mass), and the output of each of these cells (ß-cell function). In both T1D and T2D significant amounts of ß-cell mass are lost. A more comprehensive understanding of how ß-cell mass changes during the course of diabetes may allow more targeted therapy strategies. However, today no biomarkers are available to monitoring ß-cell mass.
Aims:
To develop Tmem27 as a circulating biomarker for assessing ß-cell mass in type 1 diabetes.
Methods:
Both Liquid chromatography coupled to Mass spectrometry (LC-MS) and ELISA will be used for measuring the levels of Tmem27 in blood.
2021:
The study is still active.