Tmem27- marker for ß-cell mass

Background:

The total amount of secreted insulin depends on the absolute number of the ß-cells (ß-cell mass), and the output of each of these cells (ß-cell function). In both T1D and T2D significant amounts of ß-cell mass are lost. A more comprehensive understanding of how ß-cell mass changes during the course of diabetes may allow more targeted therapy strategies. However, today no biomarkers are available to monitoring ß-cell mass.

Aims:

To develop Tmem27 as a circulating biomarker for assessing ß-cell mass in type 1 diabetes.

Methods:

Both Liquid chromatography coupled to Mass spectrometry (LC-MS) and ELISA will be used for measuring the levels of Tmem27 in blood.

2021:

The study is still active.

Primary Investigator: Per Medbøe Thorsby, MD, PhD – Hormone laboratory, OUS

Co-investigators/participants:  
Milaim Pepaj, Mcs, PhD - Senter for psykofarmakologi, Diakonhjemmet sykehus
Kari Julien, Hormone laboratory, OUS
Nina Gjerlaugsen, Hormone laboratory, OUS