Important novel data from the EPIPREG study presented in the prestigious journal Diabetes

With data from the EPIPREG sample, we identified six cross-ancestry CpG sites related to insulin resistance in pregnancy, whereof five were replicated in independent studies. From methylation quantitative trait loci analysis, we identified gene variants related to all five replicated cross-ancestry CpG sites, which were associated with several cardiometabolic phenotypes. Mediation analyses suggested that the gene variants regulate insulin resistance through DNA methylation.

DIABETES, December 19th 2022, online ahead of print: Click here