Joint International Project. Diabetes ketoacidosis (DKA) at onset of pediatric type 1 diabetes
Background: Reported rates of DKA at diabetes-onset do vary between countries, however definitions of DKA, inclusion criteria, age-range and statistical analysis differ considerably. Despite better medical care in general, and reported improvements in diabetes care, the rate of DKA at onset does not seem to improve. DKA is not only potentially lethal and related to longer hospitalization, but also a predictor of long-term poor metabolic control.
Objectives:
1) Compare current rate of DKA at onset in childhood diabetes 0-14.9 years. 2) Compare trend of DKA at onset in children 0-14.9 years between 2006 and 2016.
3) Compare effects of agegroup, gender, minority status.
4) Compare effects of seasonality.
Results: DKA prevalence varies considerably across countries, albeit generally unacceptably high and shows a slight increase between 2006-2016. Increased awareness of symptoms to prevent delay in diagnosis is warranted, especially in pre-school children, adolescents and children from ethnic minority groups.
News from 2021: The article from this project was submitted Diabetes Care 31.01.2022: “Long-term trends in the frequency of diabetic ketoacidosis at onset of pediatric type 1 diabetes and impact of the COVID-19 pandemic – International study from 12 national diabetes registries.”