Extracellular matrix and diabetic nephropathy

To improve diagnostics and increase the understanding of kidney complications in diabetes, we focus on the development of inflammation and tissue repair/fibrosis in the diabetic kidney. Our group is also involved in studies on inflammation and fibrosis in adipose tissue in obese patients and in studies of the regulation of epithelial – mesenchymal transition. All studies involve similar targets and methods and complement each other in several ways.

In the kidney project, we focus on proteomics analyses of kidney biopsies with inflammation and fibrosis targets. In relation to fibrosis, we focus on the proteoglycans, serglycin and the syndecan family.

Publications 2022:
Doncheva AI, Norheim FA, Hjorth M, Grujic M, Paivandy A, Dankel SN, Hertel JK, Valderhaug TG, Böttcher Y, Fernø J, Mellgren G, Dalen KT, Pejler G, Kolset SO. Serglycin Is Involved in Adipose Tissue Inflammation in Obesity. J. Immunol. 2022, 208121-132. doi: 10.4049/jimmunol.2100231. Epub 2021 Dec

Kristiansen O, Roland MC, Zucknick M, Reine TM, Kolset SO, Henriksen T, Lekva T, Michelsen T.J Maternal body mass index and placental weight: a role for fetal insulin, maternal insulin and leptin. Endocrinol Invest. 2022 Jul 4. doi: 10.1007/s40618-022-01842-2.

Tellez-Gabriel M, Tekpli X, Reine TM, Hegge B, Nielsen SR, Chen M, Moi L, Normann LS, Busund LR, Calin GA, Mælandsmo GM, Perander M, Theocharis AD, Kolset SO, Knutsen E. Serglycin Is Involved in TGF-β Induced Epithelial-Mesenchymal Transition and Is Highly Expressed by Immune Cells in Breast Cancer Tissue. Front Oncol. 2022 Apr 14;12:868868. doi: 10.3389/fonc.2022.868868

Geir Hetland, Magne Kristoffer Fagerhol, Veselka Petrova Dimova-Svetoslavova, Mohammad Reza Mirlashari, Nhan Trung Nguyen, Andreas Lind, Svein Olav Kolset, Arne Vasli Lund Søraas & Lise Sofie Haug Nissen-Meyer (2022) Inflammatory markers calprotectin, NETs, syndecan-1 and neopterin in COVID-19 convalescent blood donors, Scandinavian Journal of Clinical and Laboratory Investigation, DOI: 10.1080/00365513.2022.2123387

Primary Investigator: Svein O. Kolset and Trond Jenssen

Co-investigators/participants:
Knut Tomas Dalen and Frode Norheim

External collaborators:
Professor Gunnar Pejler, Uppsala University
Erik Knutsen, University of Tromsø