Diabetic nephropathy and transplantation
Group description:
Research focus
The Diabetic Nephropathy and Transplantation research group assembles the research activity of three senior researchers and their respective research groups. There is an extensive collaboration between these research groups.
Trond Jenssen. Cardiovascular disease and diabetes after organ transplantation. Clinical pancreas and islet transplantation.
Svein O. Kolset. Extracellular matrix changes in the diabetic kidney.
Hanne Scholz. Islet cell transplantation: Improvement and optimization of islet isolation, transplantation and clinical outcome.
Projects
Trond Jenssen
Posttransplant diabetes mellitus (PTDM). Occurrence, pathogenesis, risk factors, follow-up and treatment.
Improvement of kidney graft and patient survival in renal transplant patients.
Clinical outcome and improvement of beta cell replacement therapy (pancreas and islet transplantation).
Svein O Kolset
Studies on early markers of kidney changes in patients with hyperglycemia (type 1 diabetes) and restored normoglycemia (pancreas transplantation). Studies on syndecan shedding and changes in renal proteome and matrisome.
Syndecans as disease markers in population-based studies. Extracellular matrix changes due to experimental diabetic conditions in human glomerular endothelial cells.
Hanne Scholz
Improvements of pancreatic islet isolation techniques and evaluation of isolated human islets.
Cellular intervention to improve beta cell replacement.
Regenerative/repair of the endocrine compartment of the pancreas using adult stem cells.
Development of 3D bioprinting of biomimetic pancreas to treat diabetes.
Group members
Trond Jenssen, Professor OUS RH
Hanne Scholz, PhD, Leading researcher, University of Oslo
Svein O Kolset, Professor, University of Oslo
Jørn Petter Lindahl, MD, OUS RH
Anders Hartmann, Professor, University of Oslo
Karsten Midtvedt, MD PhD, OUS RH
Simen Schive, MD, PhD student, University of Oslo
Shadab Abadpour MSc, postdoc, University of Oslo
Marit Elizabeth von Düring, PhD student, University of Oslo
Espen Nordheim, MD, PhD student, OUS RH
Rasmus Kirkeskov Carlsen, PhD student, University of Oslo