ABINO: Artificial Biomimetic systems –
the Niche of Islet Organoids
This ABINO project is funded by UiO:Life Science Convergence Environment II from 2019-2023. Three research fellows (2 PhD students and 1 Postdoctoral) has been hired and will collaborate on this project.
Primary objectives:
To develop future models for diabetes research by using new strategies for stem cell differentiation.
Secondary objectives:
· Develop islet organoids from human iPS by direct differentiation in combination with pathway sensors and novel methods generated from controlled mechanical/acoustic-based perturbations
· Apply deep learning approaches to predict islet organoids reproducibility
· Develop an education app to aid education related to stem cell-based research for diabetes
· Establish a life science consortium of researchers from the department of musicology and physics at UiO, computational and cell biology at OUS, and three Center of Excellence (CoE) (RITMO, HTH, CCSE)
News from 2021:
• Presentation at the Oslo Life science conference on Feb 18th, 2021: “Music for Stem Cells. Aiming to cure diabetes with sound waves.” YouTube presentation of the ABINO project
• Diabetesfag Nr.2 Juni 2021, Diabetesforbundet: FRA ØYCELLETRANSPLANTASJON TIL PLURIPOTENTE STAMCELLER: Stamcellebehandling ved diabetes type 1. Scholz, Hanne, Abadpour, Shadab, Wang, Chencheng.
Publications 2021:
Wang C, Abadpour S, Aizenshtadt A, Chera S, Ghila L, Ræder H, Scholz H. 402.2: High Glucose Concentration Increases KATP Channel Activity but Suppresses Mitochondrial Respiration Ability in Insulin-producing Cells Regenerated From Stem Cells. Transplantation. 2021 Dec 1;105(12S1):S27. doi: 10.1097/01.tp.0000804436.14096.44. PMID: 34908336.
Abadpour, S, Wang C, Essi M. Niemi E.M, Scholz H. Tissue engineering strategies for improving beta cell transplantation outcome. Current Transplantation Report. Curr Transpl Rep (2021). doi.org/10.1007/s40472-021-00333-2
Ghila L, Legøy TA, Mathisen AF, Abadpour S, Paulo JA, Scholz H, Ræder H, Chera S. Chronically Elevated Exogenous Glucose Elicits Antipodal Effects on the Proteome Signature of Differentiating Human iPSC-Derived Pancreatic Progenitors. Int J Mol Sci. 2021 Apr 2;22(7):3698. DOI: 10.3390/ijms22073698. PubMed 33918250
Read more: UiO:LifeScience Convergence Environment II