ABINO: Artificial Biomimetic systems –
the Niche of Islet Organoids

This ABINO project is funded by UiO:Life Science Convergence Environment II from 2019-2023. Three research fellows (2 PhD students and 1 Postdoctoral) has been hired and will collaborate on this project.

Primary objectives:
To develop future models for diabetes research by using new strategies for stem cell differentiation.

Secondary objectives:
· Develop islet organoids from human iPS by direct differentiation in combination with pathway sensors and novel methods generated from controlled mechanical/acoustic-based perturbations
· Apply deep learning approaches to predict islet organoids reproducibility
· Develop an education app to aid education related to stem cell-based research for diabetes
· Establish a life science consortium of researchers from the department of musicology and physics at UiO, computational and cell biology at OUS, and three Center of Excellence (CoE) (RITMO, HTH, CCSE)

News from 2021:
• Presentation at the Oslo Life science conference on Feb 18th, 2021: “Music for Stem Cells. Aiming to cure diabetes with sound waves.” YouTube presentation of the ABINO project

• Diabetesfag Nr.2 Juni 2021, Diabetesforbundet: FRA ØYCELLETRANSPLANTASJON TIL PLURIPOTENTE STAMCELLER: Stamcellebehandling ved diabetes type 1. Scholz, Hanne, Abadpour, Shadab, Wang, Chencheng.

Publications 2021:
Wang C, Abadpour S, Aizenshtadt A, Chera S, Ghila L, Ræder H, Scholz H. 402.2: High Glucose Concentration Increases KATP Channel Activity but Suppresses Mitochondrial Respiration Ability in Insulin-producing Cells Regenerated From Stem Cells. Transplantation. 2021 Dec 1;105(12S1):S27. doi: 10.1097/01.tp.0000804436.14096.44. PMID: 34908336.

Abadpour, S, Wang C, Essi M. Niemi E.M, Scholz H. Tissue engineering strategies for improving beta cell transplantation outcome. Current Transplantation Report. Curr Transpl Rep (2021). doi.org/10.1007/s40472-021-00333-2

Ghila L, Legøy TA, Mathisen AF, Abadpour S, Paulo JA, Scholz H, Ræder H, Chera S. Chronically Elevated Exogenous Glucose Elicits Antipodal Effects on the Proteome Signature of Differentiating Human iPSC-Derived Pancreatic Progenitors. Int J Mol Sci. 2021 Apr 2;22(7):3698. DOI: 10.3390/ijms22073698. PubMed 33918250

Read more: UiO:LifeScience Convergence Environment II

Primary Investigator: Hanne Scholz

Co-investigators/participants:  
Prof. Anne Danielsen and Assoc. Prof. Alexander Refsum Jensenius, Department of Musicology and Centre for Interdisciplinary Studies in Rhythm, Time and Motion (Center of Excellence RITMO, UiO)
Prof. Anders Malthe-Sørenssen and Prof. Dag Kristian Dysthe, Department of Physics and Centre for Computing in Science Education (CoE-CCSE), UiO
Prof. Stefan Krauss, Institute of Basic Medical Sciences, UiO and Prof. Simon Rayner, Department of Medical Genetics, OUS and Center of Excellence-Hybrid Technology Hub

External collaborators: 
Prof. Helge Ræder, Department of Clinical Science, University of Bergen and Department of Pediatrics, Haukeland University Hospital, Bergen, Norway
Assoc. Prof Simona Chera, Department of Clinical Science, University of Bergen