STORK - Maternal metabolic syndrome, macrosomic newborn and pregnancy complications

STORKlogo.PNG

Background: The STORK study was initiated to address the observed increase in proportions of large babies in Norway and the growing acknowledgement that birthweight and fetal growth have consequences for health and disease both in short and long term. In Norway the proportion of babies with high birthweight/macrosomia (>4000 g) increased from approximately 17 % in 1990 to 22 % around the year 2000 when the study was planned.

Aims: The STORK study was designed to study maternal risk factors for macrosomia as reflected in the acronym STORK ”store barn og komplikasjoner”, which translates into large babies and complications. The overall aim was to study associations between maternal factors and fetal growth.

Methods: The STORK study is a prospective, longitudinal cohort study performed in the period 2001-2008. A total of 1031 healthy pregnant women who gave birth at Oslo University Hospital, Rikshospitalet were included in the study. Data included clinical, biochemical and fetal growth measurements.

News from 2022:
We have used new technology to investigate the composition of lipids in maternal plasma at different time points in pregnancy in relation to fetal growth and pregnancy complications like preeclampsia. The results from these analyses were presented at The society for Reproductive Investigations, Colorado, March 2022.

Publications 2022:

Degnes ML, Westerberg AC, Zucknick M, Powell TL, Jansson T, Henriksen T, Roland MCP, Michelsen TM. Placenta-derived proteins across gestation in healthy pregnancies-a novel approach to assess placental function? BMC Med. 2022 Jul 1;20(1):227. doi: 10.1186/s12916-022-02415-z. PMID: 35773701; PMCID: PMC9248112

Kristiansen O, Roland MC, Zucknick M, Reine TM, Kolset SO, Henriksen T, Lekva T, Michelsen T. Maternal body mass index and placental weight: a role for fetal insulin, maternal insulin and leptin. J Endocrinol Invest. 2022 Nov;45(11):2105-2121. doi: 10.1007/s40618-022-01842-2. Epub 2022 Jul 4. PMID: 35781790; PMCID: PMC9525437.

Skytte HN, Christensen JJ, Gunnes N, Holven KB, Lekva T, Henriksen T, Michelsen TM, Roland MCP. Metabolic profiling of pregnancies complicated by preeclampsia: A longitudinal study. Acta Obstet Gynecol Scand. 2023 Mar;102(3):334-343. doi: 10.1111/aogs.14505. Epub 2023 Jan 16. PMID: 36647289; PMCID: PMC9951333

Primary Investigators: Marie Cecilie Paasche Roland and Elisabeth Qvigstad

Co-investigators/participants:  
Tove Lekva
Kristin Godang
Jens Bollerslev
Tore Henriksen
Thor Ueland
Camilla Friis
Nanna Voldner
Kathrine Frey Frøslie
Gunn-Helen Moen
Sandra Steintorsdottir

External collaborators: 
Active collaborators over the past year (2021)
We are part of the Maternal-Fetal Interaction Group at Oslo University Hospital, lead by professor Trond Melbye Michelsen and collaborate on several projects linking maternal metabolism and placental physiology.
We take part in a national collaboration on gestational diabetes together with researchers from Oslo (STORK Groruddalen), Trondheim and Kristiansand.
International collaborators include the GenDIP consortium, an international consortium on genetics in gestational diabetes and Professor Jansson and Professor Powell at University of Denver, USA.