The DIASA Research Program:
Type 2 DIAbetes in South Asian immigrants - Pathophysiology, Perceptions, Prevention and Treatment
Primary objectives:
To find effective means to improve diabetes prevention, treatment and care in SA, thereby improving metabolic regulation and preventing diabetic complications, morbidity and mortality.
DIASA 1:
Find the prevalence of impaired glucose tolerance (IGT), impaired fasting glucose (IFG) and T2D in SA and NO women with pGDM 1-2 years after childbirth. Study insulin sensitivity, insulin secretion and glucose metabolism in pGDM. Study perceptions about health, disease risk, possibilities for and barriers against diabetes prevention in pGDM.
DIASA 2:
Compare SA and NO women with IGT/IFG to reveal possible differences in liver and whole body insulin sensitivity, glucose and lipid metabolism, lipidomics, fatty infiltration in liver and visceral adipose tissue.
DIASA 3:
In SA women with IGT/IFG, to test the effect of four different oral antidiabetic agents (OAD) on liver and whole body insulin sensitivity, glucose/lipid metabolism, lipidomics, fatty infiltration in liver and visceral adipose tissue.
DIASA 4:
Establish and follow a SA T2D cohort in General Practice to assess glucose regulation, treatment and complications.
News from 2022:
We have completed inclusion of 279 participants in DIASA 1 and published 2 papers describing important numbers of prevalence of prediabetes and diabetes in South Asian and Nordic women after GDM, and novel pathophysiological characteristics that helps explain the differences. DIASA 2 is almost completed and will be finished early 2023, and DIASA 3 (RCT) has recruited 11 participants, but has encountered significant challenges with recruitment.
Publications 2022:
β-Cell Function, Hepatic Insulin Clearance, and Insulin Sensitivity in South Asian and Nordic Women After Gestational Diabetes Mellitus. Sharma A, Lee-Ødegård S, Qvigstad E, Sommer C, Sattar N, Gill JMR, Gulseth HL, Sollid ST, Nermoen I, Birkeland KI.Diabetes. 2022 Dec 1;71(12):2530-2538. doi: 10.2337/db22-0622.PMID: 36112815
High prevalence and significant ethnic differences in actionable HbA1C after gestational diabetes mellitus in women living in Norway. Sharma A, Nermoen I, Qvigstad E, Tran AT, Sommer C, Sattar N, Gill JMR, Gulseth HL, Sollid ST, Birkeland KI.BMC Med. 2022 Sep 23;20(1):318. doi: 10.1186/s12916-022-02515-w.PMID: 36138475