Cardiovascular disease and end-stage renal disease in type 1 diabetes with onset before 15 years of age and long duration

(Norwegian short form: Barnediabetes og komplikasjoner)

Approximately 330 children aged 0-15 years are diagnosed with type 1 diabetes (T1D) in Norway yearly. Diabetic nephropathy (DN) is a severe complication in T1D, leading to end-stage renal disease (ESRD) and renal replacement therapy (RRT). Risk of CVD is increased in T1D, and DN is a major predictor of CVD morbidity and mortality.

In this cohort study based solely on register-data, the aims are to estimate long-term cumulative incidence of ESRD, the increased risk of CVD in long-standing T1D compared with the background population and to study the risk factors for ESRD and CVD and specifically the role of inflammation. The follow-up cohort is all newly diagnosed cases of T1d < 15 y in Norway 1973-2017.

News 2022:
The phd-candidate has been on maternity leave most of the year, but two papers have been published and the project has been presented in various forums.

Publications 2022: Saeed M., Stene L. C., Reisæter A. V., Jenssen T. G., Tell G. S., Tapia, G., Joner G., Skrivarhaug T. (2022). End-stage renal disease: incidence and prediction by coronary heart disease, and educational level. Follow-up from diagnosis of childhood-onset type 1 diabetes throughout Norway 1973–2017. Ann Epidemiol. 2022 Dec; 76:181-187.

Saeed M., Stene L. C., Ariansen I., Tell G. S., Joner G., Skrivarhaug T. (2022). Nine-fold higher risk of acute myocardial infarction in subjects with type 1 diabetes compared to controls in Norway 1973-2017. Cardiovasc Diabetol. 2022 Apr 27;21(1):59.

Primary Investigator: Geir Joner, professor emeritus, Institute of Clinical Medicine, University of Oslo

Co-investigators/participants:  
Maryam Saeed, MD, PhD-student
Torild Skrivarhaug, MD, associate professor, supervisor
Lars Christian Stene, PhD, senior researcher, co-supervisor

 
External collaborators: 
Anna Varberg Reisæter, MD, PhD, Dept. of Transplantation Medicine, Oslo university hospital. 
Trond G. Jenssen, MD, Professor, Dept. of Transplantation Medicine, Oslo university hospital and University of Oslo.
Grethe S. Tell, Professor, Department of Global Public Health and Primary Care, University of Bergen.
Ingebjørg Seljeflot, MD, Professor, Center for Clinical Heart Research, Oslo university hospital and University of Oslo
Inger Ariansen, MD, PhD, Senior researcher, Norwegian Institute of Public Health.
German Tapia, PhD, Senior researcher, Norwegian Institute of Public Health.